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Year : 1994  |  Volume : 26  |  Issue : 2  |  Page : 108-111

Hepatic metabolism of ethylene glycol (EG) and its relevance to ethanol as antidote in EG toxicity

Correspondence Address:
G Rajagopal

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Source of Support: None, Conflict of Interest: None

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Hepatic microsomal system, similar to ethanol, for the oxidation of Ethylene Glycol (EG) at the initial step has been found to exist besides the cytosolic route by alcohol dehydrogenase (ADH). Normal rat liver oxidised EG to the extent of 25.7% via microsomes and 74.3% by ADH. The EG pretreated rat liver oxidised EG by 37% and 63% via microsomes and ADH respectively. The Km value for EG oxidation by microsomes and ADH is higher than the reported Km for ethanol under similar conditions. The greater affinity of microsomal and ADH route for ethanol than for EG explains the effective role of ethanol as an antidote in cases of acute EG poisoning.


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