IPSIndian Journal of Pharmacology
Home  IPS  Feedback Subscribe Top cited articles Login 
Users Online : 477 
Small font sizeDefault font sizeIncrease font size
Navigate Here
 »   Next article
 »   Previous article
 »   Table of Contents

Resource Links
 »   Similar in PUBMED
 »  Search Pubmed for
 »  Search in Google Scholar for
 »Related articles
 »   Citation Manager
 »   Access Statistics
 »   Reader Comments
 »   Email Alert *
 »   Add to My List *
 * Requires registration (Free)

 Article Access Statistics
    PDF Downloaded108    
    Comments [Add]    

Recommend this journal


Year : 1994  |  Volume : 26  |  Issue : 1  |  Page : 49-51

Reduced phosphoinositide levels in endosulfan treated rat brain

Correspondence Address:
A Subramoniam

Login to access the Email id

Source of Support: None, Conflict of Interest: None

Rights and PermissionsRights and Permissions

The influence of the insecticide, endosulfan on the levels of phosphoinositides in rat brain was studied. Single oral administration of endosulfan (15 mg/kg) to rats, after 4 hrs, reduced phosphatidylinositol (PI) and phosphatidylinositol 4,5-bisphosphate (PIP2), without any significant effect on phosphatidylinositol4-phosphate (PIP). On the other hand, daily administration of endosulfan (15 mg/kg) for 16 days caused a marked reduction in the levels of PIP2 and PI and a moderate reduction in PIP. These effects of endosulfan were restored to near normal levels 2 weeks after cessation of the treatment. When the dosage was reduced from 15 to 5 mg/kg daily endosulfan administration for 16 days slightly reduced the levels of PI - without any significant influence on the levels of PIP and PIP2. These studies suggest possible involvement of phosphoinositide messenger system in the neurotoxicity of endosulfan.


Print this article     Email this article

Site Map | Home | Contact Us | Feedback | Copyright and Disclaimer | Privacy Notice
Online since 20th July '04
Published by Wolters Kluwer - Medknow