| SHORT COMMUNICATION |
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| Year : 1994 | Volume
: 26
| Issue : 1 | Page : 46-48 |
Anti-inflammatory activity of niosome encapsulated diclofenac sodium in arthritic rats
Naresh RA Raja, GK Pillai, N Udupa, G Chandrashekar
Correspondence Address:
Naresh RA Raja
 Source of Support: None, Conflict of Interest: None  | Check |
Synthetic analogues of liposomes prepared from non-ionic surfactants, known as niosomes, have been used as vesicular drug carriers. Diclofenacsodium has been entrapped in niosomes comprising Tween 85 and Tween 85-poloxamer F 108 mixture. Anti- inflammatory efficacy of these niosomes were compared with that of free diclofenac sodium in adjuvant induced arthritic rats. It was found that the niosomal diclofenac sodium formulations prepared by employing a 1:l combination of Tween 85 and poloxamer F 108 elicits a better and consistent anti-inflammatory activity for more than 72 hours after administration of a single dose.
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