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Year : 1994  |  Volume : 26  |  Issue : 1  |  Page : 46-48

Anti-inflammatory activity of niosome encapsulated diclofenac sodium in arthritic rats

Correspondence Address:
Naresh RA Raja

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Source of Support: None, Conflict of Interest: None

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Synthetic analogues of liposomes prepared from non-ionic surfactants, known as niosomes, have been used as vesicular drug carriers. Diclofenacsodium has been entrapped in niosomes comprising Tween 85 and Tween 85-poloxamer F 108 mixture. Anti- inflammatory efficacy of these niosomes were compared with that of free diclofenac sodium in adjuvant induced arthritic rats. It was found that the niosomal diclofenac sodium formulations prepared by employing a 1:l combination of Tween 85 and poloxamer F 108 elicits a better and consistent anti-inflammatory activity for more than 72 hours after administration of a single dose.


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