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Year : 1994  |  Volume : 26  |  Issue : 1  |  Page : 35-40

Hepatoprotective activity of “jigrine” on liver damage caused by alcohol, Carbontetrachloride and paracetamol in rats

Correspondence Address:
Kapur Vivek

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Source of Support: None, Conflict of Interest: None

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Jigrine is an Unani polypharmaceutical herbal formulation containing 1 4 medicinal plants, The effects of oral pretreatment with Jigrine (0.5 ml and 1 .O ml/ kg for 7 days ) were studied on hepatic damage induced by alcohol (40% alcohol 2.0 ml/ 100 g, po. for 21 days) and carbon tetrachloride (CCl4) (1 :1 in groundnut oil, 0.1 ml/Kg, SC. on 20th day) and also with paracetamol (750 mg/kg, ip.) in rats. Biochemical parameters like SGOT, SGPT, serum bilirubin, plasma prothrombin time and tissue lipid peroxides were estimated to assess the liver function. Alcohol - CCl4 and paracetamol treatment produced an increase in serum transaminases, bilirubin, plasma prothrombin time and lipid peroxides in liver. These effects were progressively reduced by pretreatment doses of "Jigrine". These biochemical observations were supplemented by histopathological examination of liver sections. The activity of Jigrine was also comparable to Liv - 52,a known Ayurvedic hepatoprotective formulation. The study confirms the hepatoprotective activity of Jigrine and Liv - 52 and attributes it to the antioxidant property of the formulations.


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