IPSIndian Journal of Pharmacology
Home  IPS  Feedback Subscribe Top cited articles Login 
Users Online : 1138 
Small font sizeDefault font sizeIncrease font size
Navigate Here
 »   Next article
 »   Previous article
 »   Table of Contents

Resource Links
 »   Similar in PUBMED
 »  Search Pubmed for
 »  Search in Google Scholar for
 »Related articles
 »   Citation Manager
 »   Access Statistics
 »   Reader Comments
 »   Email Alert *
 »   Add to My List *
 * Requires registration (Free)

 Article Access Statistics
    PDF Downloaded376    
    Comments [Add]    
    Cited by others 11    

Recommend this journal


Year : 1994  |  Volume : 26  |  Issue : 1  |  Page : 19-22

Effect of picroliv and silymarin on liver regeneration in rats

Correspondence Address:
Srivastava Savita

Login to access the Email id

Source of Support: None, Conflict of Interest: None

Rights and PermissionsRights and Permissions

Picroliv and silymarin are known to provide significant protection against liver damage in rats by hepatotoxic chemicals such as carbon tetrachloride, paracetamol, galactosamine and thioacetamide. Present investigation was undertaken to evaluate the effect of picroliv and silymarin on partially hepatectomized liver of rats utilising macromolecular levels, DNA, RNA synthesis and mitotic figure as indices of regeneration. The levels of DNA, RNA, protein and cholesterol increased in the regenerating liver of rats being maximum at 46 and 120 hours post partial hepatectomy (PPH). DNA and RNA synthesis increased being maximum at 24 hour PPH as indicated by the tritiated thymidine and uridine incorporation studies. Later on mitoticfigure also showed an increasing trend in the residual liver. They were further enhanced when the animals were pretreated with picroliv or silymarin. These results suggest that these agents stimulate liver regeneration in the early stages.


Print this article     Email this article

Site Map | Home | Contact Us | Feedback | Copyright and Disclaimer | Privacy Notice
Online since 20th July '04
Published by Wolters Kluwer - Medknow