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Year : 1994  |  Volume : 26  |  Issue : 1  |  Page : 13-18

Involvement of oxygen free radicals in cardioprotective effect of rutin a naturally occurring flavonoid

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Chopra Kanwaljit

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The ability of a flavonoid, rutin to inhibit the infarct size in rat heart was assessed. Anaes-thetised rats were subjected to coronary artery ligation for 72 h and infarct size was measured macroscopically using TTC staining. Systolic blood pressure and ECG were monitored. Rutin (30 mg/kg, i.p.) administered thirty minutes after CAL markedly reduced the infarct size and prevented the loss of "R" wave. However, drug treatment did not alter the heart rate and systolic blood pressure of animals. Rutin reduced coronary artery ligation - induced increase in serum malonyldialdehyde levels. In addition, rutin in vitro and in vivo demonstrated an inhibition of rat PMN-evoked and luminol-enhanced chemiluminescence. Moreover rutin significantly prevented the loss of glutathione peroxidase activity recorded 48 and 72 h after coronary artery ligation. The capacity of rutin to impair the generation of reactive oxygen species may be responsible for its beneficial effect to limit myocardial infarct size in rats.


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