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Year : 1993  |  Volume : 25  |  Issue : 4  |  Page : 224-227

Evidence for alpha-2 adrenoceptor agonist activity of hydralazine

Correspondence Address:
M C Satia

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Source of Support: None, Conflict of Interest: None

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Hydralazine (5.08 x 10-5 M to 1.5 x 10-3M ) produced a dose-dependent inhibition of field stimulation evoked responses on rat anococcygeus muscle and vas-deferens. This was antagonized competitively by yohimbine. On estrogen primed rat uterus, hydralazine produced a dose-dependent relaxation which was competitively blocked by yohimbine and propranolol but not by cimetidine. The responses to hydralazine were significantly inhibited by reserpine pre-treatment (5mg/kg, i.p., 24 h. before). Our data suggests alpha2-adrenoceptor agonist activity of hydralazine.


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