IPSIndian Journal of Pharmacology
Home  IPS  Feedback Subscribe Top cited articles Login 
Users Online : 8937 
Small font sizeDefault font sizeIncrease font size
Navigate Here
 »   Next article
 »   Previous article
 »   Table of Contents

Resource Links
 »   Similar in PUBMED
 »  Search Pubmed for
 »  Search in Google Scholar for
 »Related articles
 »   Citation Manager
 »   Access Statistics
 »   Reader Comments
 »   Email Alert *
 »   Add to My List *
 * Requires registration (Free)

 Article Access Statistics
    PDF Downloaded166    
    Comments [Add]    

Recommend this journal


Year : 1993  |  Volume : 25  |  Issue : 4  |  Page : 188-192

Medetomidine - A new selective alpha-2 adrenoceptor agonist

Correspondence Address:
B V Venkataraman

Login to access the Email id

Source of Support: None, Conflict of Interest: None

Rights and PermissionsRights and Permissions

Medetomidine, an imidazoline derivative is a lipophilic compound with selective (2-adrenoceptor agonist activity. It has a negligible binding affinity for dopaminergic, cholinergic, histaminergic, opiate, adenosine and benzodiazepine receptors. Various in vivo experiments show dose-dependent hypotensive, bradycardia, sedative, anxiolytic, mydriatic, hypothermic and analgesic effects. In general it is more potent than the other an-agonists in central and peripheral actions on (2-adrenoceptors. Effects of medetomidine can be antagonised by prior, simultaneous or subsequent administration of an-antagonists. In human trials it is shown to be well tolerated and the drug may also have therapeutic applications in humans.


Print this article     Email this article

Site Map | Home | Contact Us | Feedback | Copyright and Disclaimer | Privacy Notice
Online since 20th July '04
Published by Wolters Kluwer - Medknow