| REVIEW ARTICLE |
|
| Year : 1993 | Volume
: 25
| Issue : 4 | Page : 188-192 |
Medetomidine - A new selective alpha-2 adrenoceptor agonist
BV Venkataraman, MA Nagarani
Correspondence Address:
B V Venkataraman
 Source of Support: None, Conflict of Interest: None  | Check |
Medetomidine, an imidazoline derivative is a lipophilic compound with selective (2-adrenoceptor agonist activity. It has a negligible binding affinity for dopaminergic, cholinergic, histaminergic, opiate, adenosine and benzodiazepine receptors. Various in vivo experiments show dose-dependent hypotensive, bradycardia, sedative, anxiolytic, mydriatic, hypothermic and analgesic effects. In general it is more potent than the other an-agonists in central and peripheral actions on (2-adrenoceptors. Effects of medetomidine can be antagonised by prior, simultaneous or subsequent administration of an-antagonists. In human trials it is shown to be well tolerated and the drug may also have therapeutic applications in humans.
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