| RESEARCH PAPER
|Year : 1993 | Volume
| Issue : 3 | Page : 146-148
Drug interaction of tolbutamide with ketoconazole in diabetic rabbits
YSR Krishnaiah, S Satyanarayana, D Visweswaram
A study was carried out to find out the therapeutic implications of the tolbutamide - ketoconazole interaction in diabetic rabbits. Ketoconazole treatment (20 mgkg, oral once daily for one week) significantly increased and prolonged the antidiabetic effect of tolbutamide (40 mg/kg, oral) in diabetic rabbits. The AUC0-( and the terminal half-life of tolbutamide were increased significantly by ketoconazole indicating the decrease in its hepatic metabolism.
Source of Support: None, Conflict of Interest: None