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 RESEARCH PAPER
Year : 1993  |  Volume : 25  |  Issue : 2  |  Page : 91-94

Study of neuromuscular blockade following high dose chandonium iodide



Correspondence Address:
Y V Suri


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High dose chandonium iodide, 200, 250,300,350 and 400 'g/kg was randomly administered to 45 ASA physical status I-II patients for muscle relaxation during general and gynaecological surgery. Neuromuscular blockade was quantitated with ulnar nerve stimulation (myotest) and also assessed clinically. Time to onset of muscle relaxation, apnoea, endotracheal intubation conditions, duration of neuromuscular blockade, and haemodynamic effects of chandonium at each dose were evaluated and compared. Time to onset of muscular relaxation decreased from 72.3(15.5 to 38.0˝ 15.3 second as the chandonium dose was increased from 200 to 400 'g/kg (P< 0.01). Recovery of limb movements and hand grip after extubation was not altered clinically or statistically. However, increased recovery time to head lift for 5 seconds from 12.7˝ 9.6 to 20.1˝ 11.2 min was seen with higher dosage of chandonium. No significant haemodynamic differences between 250 and 400 'g/kg groups were observed. High doses of chandonium, may, therefore, be a useful alternative to succinylcholine to achieve similar quantitative as well as qualitative neuromuscular blockade for intubation conditions.






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