| RESEARCH PAPER
|Year : 1992 | Volume
| Issue : 3 | Page : 154-157
Toxicological profile of fluvalinate - A synthetic pyrethroid
SK Garg, SK Rastogi, VK Gupta, C Varshneya
The effect of fluvalinate (15 mg/kg, i.p) on pentobarbitone induced hypnosis and spontaneous locomotor activity in mice revealed pronounced CNS depressant effect of the compound. It produced negative inotropic and chronotropiceffects on the isolated frog heart. Spontaneous motility of isolated chicken ileum was reduced by fluvalinate in dose dependent manner. Fluvalinate (15 mg/kg, i.p) treatment for 15 days resulted in significant reduction in total leucocyte and absolute lymphocyte count. The test compound when administered for 15 days @ 15 mg/kg/day i.p., produced hepato-nephro toxicity and mild peripheral disintegration of the lymphoid nodules in spleen.
S K Garg
Source of Support: None, Conflict of Interest: None