| RESEARCH PAPER
|Year : 1991 | Volume
| Issue : 3 | Page : 143-148
Hepatoprotective activity of picroliv against alcohol-carbon tetra chloride induced damage in rat
SC Tripathi, GK Patnaik, BN Dhawan
1. The hepatoprotective activity of picroliv, the active standardised fraction of Picrorhiza kurrooa, was evaluated against alcohol -CC14 induced liver damage in rat at the doses of 3, 6 and 12 mg/kg/day, p. o. for 7 days.
2. It showed a significant dose dependent hepatoprotective activity as evidenced by lowering of the elevated levels of glutamate oxaloacetate transaminase, glutamate pyruvate transaminase, acid phosphatase, alkaline phosphatase, glutamate dehydrogenase and bilirubin in the serum of alcohol-CC14 treated rats.
3. The depleted glycogen content of liver was also restored significantly. ,
4. The activity of picroliv was compared with that of silymarin a known hepatoprotective agent.
S C Tripathi
Source of Support: None, Conflict of Interest: None