| SHORT COMMUNICATION
|Year : 1991 | Volume
| Issue : 2 | Page : 117-120
A comparison of “in-vitro” hemolytic effect of some drugs and their interaction with some stabilizers
Roy Dipali, AB Sarma
1. In vitro hemolytic effect of phenol and vit A alcohol and its esters were studied on cat, rabbit and human washed RBC suspended in isotonic saline on a comparative basis.
2. Simultaneously, time and temperature dependance study and stabilizing effect of some steroids and (-tocopheryl acetate on drug induced hemolysis were investigated.
3. Vit A alcohol was the most potent hemolytic agent among the vit A preparations. With this drug hemolysis occured even at a low temperature (20ø C).
4. While cholesterol showed no inhibition of drug induced hemolysis, (-tocopheryl acetate was the most effective stabilizer.
Source of Support: None, Conflict of Interest: None