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 RESEARCH PAPER
Year : 1990  |  Volume : 22  |  Issue : 3  |  Page : 150-154

Busulfan induced changes in lens nucleic acids



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Cherian Mary


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1. The levels of deoxyribonucleic acid (DNA) and ribonucleic acid (RNA) in the lens of control as well as Busulfan treated rats were determined. 2. The treated, non-cataractous lenses showed an increase in the DNA and RNA levels while the cataractous lenses showed decrease. 3. These changes in the nucleic acids were reflected on the protein synthesis, which was observed to increase prior to cataract formation and decrease during the progression of cataract. 4. These findings of the action of Busulfan in the above parameters have been correlated in the following ways : (1) the defense mechanism is evoked prior to cataract formation thus maintaining the lens transparency for a while (2) the cumulative action of the drug could produce a gradual inhibitory action on the nucleic acids thereby inhibiting protein synthesis and impairing the enzyme systems involved in the defense mechanism of the lens. 5. This could lead to cataractous changes in the busulfan treated lenses.






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