| RESEARCH PAPER
|Year : 1990 | Volume
| Issue : 2 | Page : 85-88
Metoprolol & Pindolol : A comparative study in essential hypertension
Razdan Gugli, Jeelani Zubaida
1. The antihypertensive effect of metoprolol and pindolol were compared in 10 young and middle aged patients of essential hypertension.
2. Patients received blind placebo therapy two weeks before the trial commenced.
3. Two groups of patients were randomely assigned to metoprolol (50 mg) 0 D. and pindolol (5 mg) B. D. treatments respectively and then crossed over for comparative evaluation for a total period of eight weeks.
4. Both treatments significantly reduced lying and standing, systolic and diastolic blood pressures as compared to placebo.
5. Comparing the treatments between zero to eight weeks in both groups, fall in blood pressure was highly significant in patients receiving pindolol in comparison to patients receiving metoprolol.
6. Blood pressure was better sustained and side-effects were less with pindolol than with metoprolol.
Source of Support: None, Conflict of Interest: None