IPSIndian Journal of Pharmacology
Home  IPS  Feedback Subscribe Top cited articles Login 
Users Online : 13297 
Small font sizeDefault font sizeIncrease font size
Navigate Here
 »   Next article
 »   Previous article
 »   Table of Contents

Resource Links
 »   Similar in PUBMED
 »  Search Pubmed for
 »  Search in Google Scholar for
 »Related articles
 »   Citation Manager
 »   Access Statistics
 »   Reader Comments
 »   Email Alert *
 »   Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed1158    
    Printed85    
    Emailed0    
    PDF Downloaded84    
    Comments [Add]    

Recommend this journal

 

 RESEARCH PAPER
Year : 1989  |  Volume : 21  |  Issue : 3  |  Page : 81-89

Differential effects of calcium and sodium on the mechanical responses to various agonists in rat vas-deferens and anococcygeus muscle



Correspondence Address:
R H Razdan


Login to access the Email id

Source of Support: None, Conflict of Interest: None


Rights and PermissionsRights and Permissions

1. Noradrenaline (NA), 5-hydroxytryptamine (5-HT) phenylephrine (PHE), methoxamine (ME), dopamine (DA) and carbachol produced dose dependent contraction of rat vas-deferens and rat anococcygeus muscle. 2. In presence of D-600 (41 uM) or in calcium free PSS, the responses to NA, 5-HT and carbachol were not affected significantly, whereas the responses to PHE, ME and DA were significantly decreased as compared to the control in rat anococcygeus muscle. 3. However, in rat vas-deferens, all these agonists failed to produce any response in the preparation bathed in Ca++ free PSS or PSS containing D-600. 4. Indanidine (Sgd 101/75) produced dose dependent contraction of rat anococcygeus and rat vasdeferens. The contractile responses to indanidine in rat anococcygeus muscle were comparable to that of NA (about 75%), however, in rat vas-deferens it was of smaller magnitude (17% of NA max). 5. In rat anococcygeus and in rat vas-deferens the responses to indanidine were abolished in the presence of D-600 or Ca++ free PSS. 6. In zero sodium the responses to NA, PHE, 5-HT, DA, ME and carbachol were not affected significantly in either rat anococcygeus or vas-deferens. However the responses to indanidine were significantly inhibited in rat anococcygeus. While in rat vas-deferens, indanidine failed to produce any contraction in zero sodium. 7. It is concluded that there may be different post receptor regulatory mechanisms controlling calcium movements responsible for the contraction of rat anococcygeus and rat vas-deferens.






[PDF]*


        
Print this article     Email this article

Site Map | Home | Contact Us | Feedback | Copyright and Disclaimer
Online since 20th July '04
Published by Wolters Kluwer - Medknow