IPSIndian Journal of Pharmacology
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Year : 1989  |  Volume : 21  |  Issue : 3  |  Page : 104-106

Modification of histamine induced wheal suppression method and its utility in bioassay of topical steroids



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P K Singh


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1. Histamine induced wheal suppression technique of Reddy and Singh (1976) has been modified by calculating volume of the wheal. 2. Height of the wheal was measured with the help of a spherometer to calculate its volume by the relation (r2h. 3. Potency of two topical corticosteroid preparations (halcinonide 0.1% and hydrocortisone l .0%) was assessed on ten healthy volunteers in a double blind study. 4. The effect of tachyphylaxis was observed with both the steroids within a week, still earlier with potent steroid.A four days rest was enough to bring back the skin to its pretreatment level.






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