IPSIndian Journal of Pharmacology
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Year : 1988  |  Volume : 20  |  Issue : 2  |  Page : 135-142

Mechanism of noradrenaline release by histamine in the estrogen primed rat-uterus

Correspondence Address:
R K Goyal

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Source of Support: None, Conflict of Interest: None

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1. Histamine (9.7 X 10-7M - 2.3 X 1O-5M) produced a dose dependent relaxation of the estrogcn primed rat uterus. These reponses were significantly potantiated by nialamide (2.2 X 10-6M). pyrogallol (7.9 X 10-5 M) and desmathylimipramine (4.3 x 10-6 M). 2. Guansthidine (2.5 x 1D-6M) produced time dependent effect on histamine induced responses. The responses to histamine were significantly potentiated at the end of 10 min exposure to guanethidine However. after 30 min there was significant time-dependent inhibitinn of the responses to histamine. 3. The responses to histamine were inhibited significantly when NaCl concentration of the perfusion fluid (de-Jalon) was reduced to zero. Further. When Cacl 2 concentration (0.25 mM) in the NaCI free solution was increased to 1.0 mM. the responses to histamine were restored to the normal. 4 . Unlike that of histamine the absence of Nacl did not effect the responses to tyramine or isoprenaline in to rat uterus. 5. Our data suggest that the mechanism of release of noradrenaline in the rat uterus may be consequence of pre-synaptic H2 receptor stimulation.


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