| SHORT COMMUNICATION |
|
| Year : 1987 | Volume
: 19
| Issue : 2 | Page : 134-139 |
Imipramine and d-tubocurarine interaction in vivo
BG Patel, MI Bhatt, KC Dave
Correspondence Address:
B G Patel
 Source of Support: None, Conflict of Interest: None  | Check |
1. A non-paralysing dose of d-tubocurarine (25 (g/kg) caused quicker onset of hind limb paralysis of a long duration in rats pretreated with imipramine (15,30 mg/kg). Pretreatment with imipramine (10,15,30 mg/kg) in rabbits reduced the minimum effective head drop dose of d-tubocurarine.
2. Potentiating effect persisted upto 24 h, and total recovery from the effect appeared after 48 h, of imipramine (30 mg/kg) pretreatment,
3. It is suggested that the potentiation of the action of d-tubocurarine by imipramine may be of clinical importance, in patients receiving imipramine.
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