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Year : 1987  |  Volume : 19  |  Issue : 2  |  Page : 134-139

Imipramine and d-tubocurarine interaction in vivo

Correspondence Address:
B G Patel

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Source of Support: None, Conflict of Interest: None

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1. A non-paralysing dose of d-tubocurarine (25 (g/kg) caused quicker onset of hind limb paralysis of a long duration in rats pretreated with imipramine (15,30 mg/kg). Pretreatment with imipramine (10,15,30 mg/kg) in rabbits reduced the minimum effective head drop dose of d-tubocurarine. 2. Potentiating effect persisted upto 24 h, and total recovery from the effect appeared after 48 h, of imipramine (30 mg/kg) pretreatment, 3. It is suggested that the potentiation of the action of d-tubocurarine by imipramine may be of clinical importance, in patients receiving imipramine.


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