| RESEARCH PAPER
|Year : 1986 | Volume
| Issue : 4 | Page : 223-226
An experimental study on antibiotic-oral contraceptive interactions
P Sharma, AL Sharma, S Kulshrestha, DK Hazra, RK Srivastava, SS Mishra
1. Oral contraceptive (OC)-antibiotic (AB) interaction wasexplored in rabbits by estimating plasma Concentration (c) of AB and oestradiol (OD) after separate and concomitant administration.
2. Ampicillin (AMP), oxytetracycline (TET) and chlroamphenicol (CPL) concentrations following single oral administration were same in control as well as in OC pretreated (30 days) rabbits.
3. c-OD in OC pretreated group (30 days) was significantly reduced when OC and AB were concurrently given for 5 days. c-OD remained significantly low in AMP treated group on continuation of OC for 5 more days.
4. Reduction in c-OD by AB may account for contraceptive failure.
Source of Support: None, Conflict of Interest: None