IPSIndian Journal of Pharmacology
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 RESEARCH PAPER
Year : 1986  |  Volume : 18  |  Issue : 2  |  Page : 95-99

Influence of neurohumors on motility and transverse migration of infective larvae of Haemonchus contortus



Correspondence Address:
K C Singhal


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Source of Support: None, Conflict of Interest: None


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1. Evidence has collected that neurohumors play a significant role in regulating the worm movements. Addition of acetylcholine, 5-HT, histamine or adrenaline to larval suspension caused initial increase in the motility of the larvae followed by paralysis. 2. The onset of action was immediate following addition of 5-HT, histamine and adrenaline. However, the effect of Ach was after a latent period. 3. The effect of 5-HT, histamine and adrenaline appear to be only depressent caused by hyperpolarization of the nerve-muscle complex and the initial stimulation could be due to the irritant effect of these chemicals. 4. The spastic paralysis caused by Ach indicate that the drug causes deplorization at the neuromuscular junction. 5. All the four neurohumoral agents caused concentration related inhibition of the transverse migration of the infective larvae through soil particles.






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