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Year : 1985  |  Volume : 17  |  Issue : 4  |  Page : 201-204

Influence of diazepam and its solvent on the effect of neuromuscular blocking agents

Correspondence Address:
M I Bhatt

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Source of Support: None, Conflict of Interest: None

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1. The effect of commercially available solution of diazepam and its solvent was investigatedon frog rectus abdominis muscle and sciatic nerve-gastrornemius muscle preparation of-dog. 2. Diazepam and diazepam solvent both equally potentiated acetylcholine induced contracture and both also partially but equally antagonized gallamine induced inhibition of acetylcholine contracture on isolated rectus abdominis muscle of frog. 3. Diazepam and diazepam solvent both antagonized gallamine induced blockade, while augmented that produced by succinylcholine on the sciatic nerve gastrocnemius muscle preparation of dog. 4. The present study suggests that decurarizing effect of commercially available solution of diazepam reported earlier is not of diazepam itself but of its solvent only.


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