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 RESEARCH PAPER
Year : 1985  |  Volume : 17  |  Issue : 1  |  Page : 34-41

Central cholinergic involvement in clonidine and shock induced aggression and its modification by nitrazepam, haloperidol and propranolol: an experimental study in albino rats



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K Jain


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1. Clonidine (50 mg/kg ip) induced a peculiar aggressive behavior in mice, associated with drastically reduced ACh level (p < 0.0001) in the whole brain. Footshock also caused significant reduction in ACh level (p < 0.001). 2. Perhaps central cholinoceptive mechanisms are involved in both clonidine and shock- induced aggression (CIA and SIA). Nitrazepam (NTZ), haloperidol (HAL) and propranolol (PROP) reduced the ACh level(s) significantly (p< 0.001). 3. All the drugs decreased the biting/fighting episodes. However, correlation between the anti-aggressive action and the changes in ACh - lowering effect of CIA and SIA caused by these drugs was absent. 4. Nitrazepam, HAL, AND PROP significantly raised the diminished CIA-induced Ach level (p <0.001), but they potentiated the Ach-lowering effect of SIA. When HAL or PROP administration preceded CIA or SIA, they antagonized the Ach-lowering effect of drug(s) alone. 5. Interestingly NTZ, administered prior to CIA or SIA was fount to be further potentiate (p <0.001) the Ach reduction caused by NTZ alone.






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