| RESEARCH PAPER
|Year : 1983 | Volume
| Issue : 3 | Page : 189-195
Chlorpromazine induced inhibition of pinnal reflex in mice: involvement of central dopaminergic system
PP Singh, AY Junnarkar, DR Shridhar
Chlorpromazine (CPZ) inhibited the pinnal reflex in mice in a dose dependent manner. Studies were conducted using agents influencing adrenegric and dopaminergic systems in order to study the mechanism of action. Reserpine, alpha-methyl-p-tyrosine, 6-hydroxydopamine and yohimbine blocked the inhibition of pinnal reflex induced by CPZ. None of the interacting agents had any per se effect on the pinnal reflex. Phenoxy-benzamine, phentolamine and propranolol did not alter the CPZ induced inhibition of pinnal reflex. Imipramine, a rettptake blocker of noradrenaline, did not potentiate the effect of the sub-minimal dose of CPZ. However, sub minimal effect of CPZ on pinnal reflex was potentiated by diethyldithiocarbamate and also by a higher but not by a lower dose of apomorphine. Haloperidol blocked the CPZ induced inhibition of the pinnal reflex. The results suggest that the chlorpromazine-induced inhibition of the pinnal reflex is central in origin and mediated by dopamine at the postsynaptic dopaminergic receptors.
P P Singh
Source of Support: None, Conflict of Interest: None