| RESEARCH PAPER
|Year : 1983 | Volume
| Issue : 3 | Page : 165-170
Effect of L-Dopa, amantadine and tremorine on brain monamines
SD Seth, BP Srinivasan, HH Siddiqui, SP Sivam
The effect of L-dopa, alone and in combination, on brain dopamine, norepinephrine, serotonin, 5-hydroxyindole acetic acid and monoamine oxidase activity was investigated in tremorine induced tremor syndrome in rats. L-dopa, alone and in combination with amantadine, produced a remarkable rise in dopamine and 5-hydroxyindole acetic acid and a reduction in serotonin content.Tremorine failed to influence any of the parameters. The findings suggest that L-dopa and amantadine have pro-found effects on brain biogenic amines which may account for the therapeutic effects as well as behavioural side-effects frequently encountered in clinical practice.
S D Seth
Source of Support: None, Conflict of Interest: None