| RESEARCH PAPER
|Year : 1983 | Volume
| Issue : 2 | Page : 101-105
Hyaluronidase-isoprenaline interaction on myocardial lesions in albino-rats
AK Kela, SS Gambhir, DP Thombre, LP Reddy, UC Rai, S Muthiyan, S Ramakrishnan
The effect of hyaluronidase on the myocardial infarction induced by the administration of isoprenaline (IP) was investigated in rats. Hyaluronidase, administered intravenously following the IP injection, failed to alter the severity of myocardial lesions, as judged by ECG recordings, serum CK estimations and histology. These findings differ from the reported beneficial effects of hyaluronidase in myocardial infarction produced after coronary ligation. This discrepancy may be due to a different mechanism of production of myocardial infarction by the present method and better penetration of IP in the myocardial cells, thereby enhancing rhe toxicity of its higher doses.
A K Kela
Source of Support: None, Conflict of Interest: None