| RESEARCH PAPER
|Year : 1982 | Volume
| Issue : 4 | Page : 345-350
Preliminary observation regarding the cataleptogenic activity of maprotiline in the mouse
JJ Balsara, VR Mane, VP Gada, NV Nandal, AG Chandorkar
Maprotiline (5-40 mg/kg ip) was found to induce catalepsy in mice. Treatment with apomorphine (2.5 and 5 mg/kg. ip) and atropine (20 mg/kg, ip) significantly reduced the cataleptic effect of maprotiline. Further, pretreatment with maprotiline (2.5-10 mg/kg, ip) significantly antagonised apomorphine-induced cage climbing behaviour in mice. The results suggest that the cataleptogenic effect of maprotiline is probably due to blockade of post-synaptic striatal dopamine receptors.
J J Balsara
Source of Support: None, Conflict of Interest: None