IPSIndian Journal of Pharmacology
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Year : 1982  |  Volume : 14  |  Issue : 4  |  Page : 333-340

Effect of caffeine and dextro-amphetamine on muscle strength and physical endurance in albino rats: A Bio-chemical study.

Correspondence Address:
K Jain

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Source of Support: None, Conflict of Interest: None

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Caffeine exhibited significant improvement in swimming endurance performance and pulling strength, while d-amphetamine showed improvement in swimming performance only, and insignificantly reduced the pulling strength in rats. Neither of the two drugs suppressed blood lactic acid (BLA) levels, or replenished skeletal-muscle glycogen (SMG) stores. In this study there was no correlation between the "anti-fatigue" action and BLA rise antagonism, which otherwise is an important mechanism involved in the increase of endurance performance. The findings have been discussed in view of available literature.


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