| RESEARCH PAPER
|Year : 1982 | Volume
| Issue : 4 | Page : 319-323
Effect of Mk-212 on isolated guinea-pig heart
UP Patel, RK Goyal, SC Verma
MK-212 ; (6-Chloro-2-(1-piperazinyl)-pyrazine) (5x 10-8 to 4x10-7M) produced dose-dependent positive inotropic effects on guinea-pig heart. The responses to MK-212 were competitively blocked by mepyramine maleate and cyproheptadine. Metiamide did not alter the resonses to MK-212 on guinea-pig heart.The responses to MK-212 were also Inhibited competitively by propranolol. Reserpinization inhibited the responses to MK-212 completely. Our findings suggest that, MK-212 induced positive inotropic effect in guinea-pig heart 18 due to stimulation of post-syoaptic beta-receptors, involving the release of noradrenaline which follows the stimulation of either presynaptic serotonin or H1- histamine receptors.
U P Patel
Source of Support: None, Conflict of Interest: None