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 RESEARCH PAPER
Year : 1982  |  Volume : 14  |  Issue : 4  |  Page : 319-323

Effect of Mk-212 on isolated guinea-pig heart



Correspondence Address:
U P Patel


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MK-212 ; (6-Chloro-2-(1-piperazinyl)-pyrazine) (5x 10-8 to 4x10-7M) produced dose-dependent positive inotropic effects on guinea-pig heart. The responses to MK-212 were competitively blocked by mepyramine maleate and cyproheptadine. Metiamide did not alter the resonses to MK-212 on guinea-pig heart.The responses to MK-212 were also Inhibited competitively by propranolol. Reserpinization inhibited the responses to MK-212 completely. Our findings suggest that, MK-212 induced positive inotropic effect in guinea-pig heart 18 due to stimulation of post-syoaptic beta-receptors, involving the release of noradrenaline which follows the stimulation of either presynaptic serotonin or H1- histamine receptors.






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