| SHORT COMMUNICATION
|Year : 1982 | Volume
| Issue : 3 | Page : 273-276
Anti-inflammatory, anticonvulsant and local anaesthetic activity of clonidine – A preliminary report
P Jain, VK Pendse, KP Singh, SD Suthar
Clonidine, a potent centrally acting antihypertensive drug was screened for anti-inflammatory, anticonvulsant and local anaesthetic activity. In carrageenin-induced inflammation it showed a significant dose dependent anti-inflammatory effect. Clonidine failed to show any anticonvulsant effect against maximal electro-shock convulsions in rats, however it exhibited significant local anaesthetic activity. Diuresis, piloerection and convulsions were observed in higher doses.
Source of Support: None, Conflict of Interest: None