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 RESEARCH PAPER
Year : 1982  |  Volume : 14  |  Issue : 3  |  Page : 233-237

Assessment of myocardial damage by 99mTc-pyrophosphate and serum enzyme profile in rats



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T J Hemnani


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An attempt was made to correlate the damage to myocardium as assessed by 99mTc -pyrophosphate uptake by heart with serum enzyme profile (SGOT) as a function of time in rats using adrenaline model. It was seen that the changes with both pyrophosphate uptake and SGOT levels were nearly parallel but the magnitude of change was much more with pyrophosphate uptake and hence gradation was more easy with the latter. Hence this model may be used for the evaluation of cardioprotective drugs and newer infarct seeking radio pharmaceuticals in animals .






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