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 RESEARCH PAPER
Year : 1982  |  Volume : 14  |  Issue : 3  |  Page : 229-232

Effect of pyrantel pamoate on the development of hook-worm



Correspondence Address:
K C Singhal


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Pyrantel pamoate. a broad spectrum anthelmintic, was investigated for its effect on the developmental stages of sheep hook worm, Haemonchus controlus. Addition of pyrantel pamoate to the faeces charcoal mixture caused concentration-related inhibition of transformation of Haemonchus contorlus seggs to infective larvae, the LC50 and LC90 being 54.95 ˝ 6.90 and 400.00 ˝ 49.10 mcg, respectively. On infective larvae, pyrantel pamoate produced contracture and decrease in motility leading to irreversible. paralysis.






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