| RESEARCH PAPER
|Year : 1981 | Volume
| Issue : 4 | Page : 325-331
Chemical and pharmacological studies on Solanum giganteum jacq
YV Rao, SK Bandopadhyay, SB Acharya, PK Debnath, T Ganguly, SN Ganguly
A steroidal alkaloid with an additional-hydroxy and aminogroup was isolated from roots of Solanum giganteum Jacq (N. 0. Solanaceae). The compound decreased spontaneous motor activity and enhanced pentobarbitone hypnosis in albino mice. It produced spasmogenic responses on isolated smooth muscles like rat fundus and oestronised rat uterus and positive inotorpic effect on perfused frog's heart. Hypnotic potentiating effect in mice and spasmogenic responses on isolated smooth muscles were blocked by methysergide and BW501 C67 respectively suggesting that the compound possesses serotonin-like activity.
Y V Rao
Source of Support: None, Conflict of Interest: None