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 RESEARCH PAPER
Year : 1979  |  Volume : 11  |  Issue : 4  |  Page : 265-268

Investigations into the positive inotropic effect of ST 600 [2-(5-fluoro-O-toluidine)-2-imidazoline hydrochloride] on isolated hearts



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A Veeranjaneyulu


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. ST 600 [2-(5 fluoro-O-toluidine)-2 imidazoline hydrochloride] in doses 2.5 to 40 'g injected into the isolated perfused guineapig heart caused an increase in contractile force. The effects of ST 600 were blocked by metiamide (3x 10-5M). Mepyramine or reserpine treatment (5mg/kg i.p.; 24 h prior to the experiment) did not influence the contractile effects of ST 600. Clonidine and ST 600 both produced parallel dose-response curves, which were competitively antagonized by H1-receptor antagonists burimamide and metiamide respectively. It is suggested that the inotropic action of ST 600 is due to stimulation of histamine H2-receptors.






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