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Year : 1978  |  Volume : 10  |  Issue : 4  |  Page : 295-300

Morphine induced subsensitivity to acetylcholine in smooth muscle

Correspondence Address:
PDMV Turlapaty

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Source of Support: None, Conflict of Interest: None

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. Morphine depressed the contractile responses of guineapig ileum to acetylcholine (ACh) in a graded and time-dependent manner. This action of morphine was specific since it did not alter the contractile responses to histamine and potassium chloride. Naloxone, a specific morphine antagonist, failed to prevent morphine-induced subsensitivity to ACh indicating that the action of morphine is not mediated through opiate receptors. High calcium decreased significantly the degree of morphine-induced subsensitivity.


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