| RESEARCH PAPER |
|
| Year : 1978 | Volume
: 10
| Issue : 4 | Page : 295-300 |
Morphine induced subsensitivity to acetylcholine in smooth muscle
PDMV Turlapaty, S Jayasundar, S Ramaswamy
Correspondence Address:
PDMV Turlapaty
 Source of Support: None, Conflict of Interest: None  | Check |
.
Morphine depressed the contractile responses of guineapig ileum to acetylcholine (ACh) in a graded and time-dependent manner. This action of morphine was specific since it did not alter the contractile responses to histamine and potassium chloride. Naloxone, a specific morphine antagonist, failed to prevent morphine-induced subsensitivity to ACh indicating that the action of morphine is not mediated through opiate receptors. High calcium decreased significantly the degree of morphine-induced subsensitivity.
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