| RESEARCH PAPER
|Year : 1978 | Volume
| Issue : 3 | Page : 207-213
Excitatory spinal muscarinic cholinoceptors for vasomotor regulation in the dog
VK Srivastava, RK Srivastava, G Tayal, DN Prasad
Role of spinal muscarinic cholinoceptors in vasomotor regulation was studied by observing the effect of m-holinoceptor agonists and antagonists on blood pressure and carotid occlusion response when the drugs were localised within the spinal cord by intrathecal injection in dogs. Intrathecal oxotremorine (1-10 (g) and neostigmine (100-200 (g) raised B. P. and potentiated carotid occlusion response while ethybenztropine (250-l000( (g) and atropine sulphate (g-12 mg) decreased the B. P. and inhibited carotid occlusion response. Furthermore, ethybaztropine prevented the rise in B.P. and potentiation of carotid occlusion response induced by oxotremorine. It is concluded that spinal m-cholinoceptors are excitatory in nature and that at least some of the descending excitatory neurons from supraspinal vasomotor apparatus are possibly m-cholinergic.
V K Srivastava
Source of Support: None, Conflict of Interest: None