IPSIndian Journal of Pharmacology
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Year : 1978  |  Volume : 10  |  Issue : 3  |  Page : 191-200

Biochemical studies of betel nut constituents

Correspondence Address:
N M Shivapurkar

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Source of Support: None, Conflict of Interest: None

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. To study the biochemical action of different betel nut constituents, aqueous extract and polyphenolic fraction of dried Mangalore betel nut were injected i. p. to Swiss mice and different biochemical parameters viz. nucleic acids, protein, sialic acid and glycogen were measured in liver, lung, kidney and muscle tissues. Arecoline and tannic acid were injected in the same manner for comparison. It was observed that polyphenolic fraction and tannic acid decreased nucleic acid and protein content in almost all the tissues. Both of them decreased glycogen and increased sialic acid in lung and kidney tissues. Many carcinogens behave similarly but the above reported changes may be merely a manifestation of the subtle toxic effects exerted by these extracts. In-depth studies on the various metabolic parameters may help to locate their precise mode of action.


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