| SHORT COMMUNICATION
|Year : 1978 | Volume
| Issue : 2 | Page : 167-169
Phenformin on blood lactate in dogs
RB Patel, TP Gandhi, GF Shah, VC Patel, RN Gilbert
Administration of phenformin 10-20 mg/kg, chlorpropamide 20 mg/kg and their combination 10 mg/kg and 20 mg/kg respectively p.o. daily to normal dogs for 12 weeks were studied for the. effect on resting blood lactic acid level. Phenformine 10 mg/kg daily either alone or in combination with chlorpropamide does not increase the blood lactate level. Administration of a high dose (50 mg/kg) of phenformin in a slow i.v. drip for 4 consecutive days to normal healthy dogs does not induce hyperlactacidaemia.
R B Patel
Source of Support: None, Conflict of Interest: None