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 RESEARCH PAPER
Year : 1978  |  Volume : 10  |  Issue : 1  |  Page : 7-14

Studies on blood enzymes during acute toxicity of O-ethyl-S,S-diphenylphosphorodithioate (Hinosan) in buffalo calves



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J K Malik


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. Acute toxicity studies of O-ethyl-S, S-diphenyl phosphorodithioate (Hinosan, Bayer 78418), an organophosphate fungicide and insecticide, were conducted on buffalo calves. The effect of hinosancm blood cholinesterase demonstrated that it is an effective inhibitor of cholinesterase activity in vivo Hinosan in single oral doses of 30, 45 and 60 mg/kg resulted in maximal inhibition of blood cholinesterase to the extent of 59.3%, 71.4% and 73.9% respectively after 12-24 h of its administration. The onset of severe toxic symptoms with higher doses (45 and 60 mg/kg) correlated well with the maximum inhibition of cholinesterase activity. The inhibited enzyme recovered slowly after 4 weeks, it returned to 86.5 % and 81.6 % of pretreatment level with 30 and 45 mg/kg doses of hinosan respectively. Hinosan in higher doses viz. 45 and 60 mg/kg increased the SGPT levels while, elevation in levels of SGOT was found with all the doses, suggesting that hinosan can induce internal tissue damage. Hinosan (30 and 45 mg/kg) resulted in gradual rise of SGOT levels which approached its highest at 2nd week and started recovering afterwards but remained significantly elevated 4 weeks after its administration. No change in serum alkaline phosphatase activity was observed.






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