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 RESEARCH PAPER
Year : 1978  |  Volume : 10  |  Issue : 1  |  Page : 27-34

Neuropharmacological studies of histamine and its precursor L-histidine in rats



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C P Trivedi


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. The effects of intracerebro-ventricularly injected histamine and pretreatment with L-histidine. The precursor of histamine, was studied on the central nervous system of rats. An increase in spontaneous motor activity, reduction of pentobarbitone sleeping time, reduction in the threshold of chemoshock and electric shock seizures was observed with histamine and L-histidine. They were also found to inhibit the ingestive behaviour and exert an analgesic effect on rats.






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