IPSIndian Journal of Pharmacology
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Year : 1977  |  Volume : 9  |  Issue : 3  |  Page : 221-224

Antiinflammatory, immunosuppressive and some related pharmacological actions of the water extract of Neem Giloe (Tinospora cordifolia): A preliminary report

Correspondence Address:
V K Pendse

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Source of Support: None, Conflict of Interest: None

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The water extract of the stem of Neem Giloe (Tinospora cordifolia), an Indian Indigenous plant, was screened for anti-inflammatory, analgesic and antipyretic actions in albino rats and immunosuppressive effect in albino rabbits. lt significantly inhibited acute inflammatory response evoked by carrageenin in a doss of 50 mg/100 g given orally and intraperitoneally. In chronic inflammation produced by croton-oil in granuloma pouch technique, 20 mg/100 g of the water extract significantly inhibited granulation tissue response; the reduction in exudative response and increase in t he weight of adrenal glands were not significant. A significant inhibition of primary and secondary phases was observed In adjuvant-induced arthritis. It significantly inhibited antibody formation by typhold "H" antigen. A mild analgesic effect of its own as well as potentiation of morphine analgesia were possessed by the extract but it was devoid of antipyretic effect.


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