IPSIndian Journal of Pharmacology
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 RESEARCH PAPER
Year : 1976  |  Volume : 8  |  Issue : 4  |  Page : 205-210

Further studies on the corticosteroid like activity of the lipid extract of Periplaneta americana (cockroach)



Correspondence Address:
S R Dasgupta


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Source of Support: None, Conflict of Interest: None


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In continuation of search by the present group of workers fore scientific basis behind the therapeutic application of common domestic insect, Periplaneta americana (cockroach) in bronchial asthma by the Iaity, the effect of the lipid extract of cockroach on the ascorbic acid content of the adrenal cortex and liver of albino rats has been studied to provide further evidence in favour of the corticosteroid like properties of this extract. A simultaneous study with prednisolone acetate (Deltacortil) has been made for comparison. Besides the changes in the blood picture of rats, characterised by both relative and absolute eosinopenia 3.6 hours after the administration of the lipid extract or prednisolone. a marked increase was noted in the ascorbic acid content of the adrenocortical tissue and liver in either case. After eighteen hours the blood picture returned to normal but the rise in the ascorbic acid content in adrenal cortex and liver continued even after twenty four hours. This may be indicative of a possible role of the lipid or prednisolone in the endogenous synthesis of ascorbic acid in rats.






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