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 RESEARCH PAPER
Year : 1975  |  Volume : 7  |  Issue : 3  |  Page : 24-33

Pharmacological actions of aqueous and alcoholic extracts of roots of Cichorium intibus, Linn



Correspondence Address:
M N Jindal


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Source of Support: None, Conflict of Interest: None


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Both the alcoholic and aqueous extracts of Cichorium Intibus (2OO-800 mg/kg, i. p.) exhibited anti-MES and anti-metrazole but limited antistrychnine activity. These extracts (2OO-800 mg/kg. i.p.) potentiated pentobarbitone and ethanol induced hypnosis in mice. exhibited analgesia [ED50 for alcoholic and aqueous extracts were 520 (505-541) and 480 (439-510) mg/kg, i. p. respectively], and potentiated morphine analgesia in rats. There was dose related antipyretic effect against LSD induced hyperpyrexia in rats. Cardio-vascular, smooth muscle and skeletal muscle actions appear to be cholinergic in nature. Both the extracts showed anti-inflammatory activity against formalin induced oedema. There is a considerable gap in between the pharmacodynamic and the toxic doses.






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