| RESEARCH PAPER
|Year : 1975 | Volume
| Issue : 3 | Page : 24-33
Pharmacological actions of aqueous and alcoholic extracts of roots of Cichorium intibus, Linn
MN Jindal, VK Patel, NB Patel
Both the alcoholic and aqueous extracts of Cichorium Intibus (2OO-800 mg/kg, i. p.) exhibited anti-MES and anti-metrazole but limited antistrychnine activity. These extracts (2OO-800 mg/kg. i.p.) potentiated pentobarbitone and ethanol induced hypnosis in mice. exhibited analgesia [ED50 for alcoholic and aqueous extracts were 520 (505-541) and 480 (439-510) mg/kg, i. p. respectively], and potentiated morphine analgesia in rats. There was dose related antipyretic effect against LSD induced hyperpyrexia in rats. Cardio-vascular, smooth muscle and skeletal muscle actions appear to be cholinergic in nature. Both the extracts showed anti-inflammatory activity against formalin induced oedema. There is a considerable gap in between the pharmacodynamic and the toxic doses.
M N Jindal
Source of Support: None, Conflict of Interest: None