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 RESEARCH PAPER
Year : 1975  |  Volume : 7  |  Issue : 3  |  Page : 1-9

Anti-inflammatory activity of flupenthixol: A new antidepressant



Correspondence Address:
J L Godhwani


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Flupenthixol, a new antidepressant was investigated for its anti-inflammatory activity. It inhibited inflammatory oedema induced by carrageenin and 5-HT and reduced exudate formation and granulation tissue in croton oil-induced granuloma pouch technique. The ability of the drug to suppress inflammatory response to carrageenin is attenuated in animals pretreated with either reserpine or dihydroergotamine (but not with propranolol). This suggests the involvement of adrenergic system. at the level of alpha-receptors. In mediating the anti-inflammatory activity of the drug. However. there is also a direct component of anti-inflammatory action of flupenthixol since its effectiveness at higher dose-level remained unchanged in reserpinized animals. The combined use of flupenthixol and phenyl-butazone produced anti-inflammatory effect which was greater than that observed with the use of either drug alone but no such enhanced response with betamethasone was elicited. The anti-inflammatory activity of the drug was not the result of local irritation as evidenced by its efficacy following oral administration and its ineffectiveness on local injection into the rat's paw.






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