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Figure 1: Diagrammatic representation of novel targets of ALS. Novel drug targets for amyotrophic lateral sclerosis: (1) Mitochondiral activity modulator prevents mitochondrial DNA damage; (2) Glutamate inhibitors decreases excitotoxicity and improve motor function; (3) Protein aggregation inhibitor prevent protein misfolding and accumulation; (4) MicroRNA modulator regulates apoptosis, Necroptosis, and inflammation; (5) Axonal transport modulator regulates posttranslational modifications of RNA binding proteins and other proteins; (6) Macrophage regulator prevents neuroinflammation and subsequent motor neurons degeneration; (7) C90rf72 inhibitor prevent modulation of downstream pathways; (8) Reactive oxygen species inhibitor prevent mitochondrial dysfunction and cell damage; (9) Apoptotic inhibitor prevent apoptosis and cell damage; (10) SOD1 inhibitor prevents protein aggregation; (11) Creatine kinase 1 inhibitor prevents phosphorylation of TDP-43 binding protein; (12) Neuromuscular junction modulator prevent loss of neuromuscular junction integrity

Figure 1: Diagrammatic representation of novel targets of ALS. Novel drug targets for amyotrophic lateral sclerosis: (1) Mitochondiral activity modulator prevents mitochondrial DNA damage; (2) Glutamate inhibitors decreases excitotoxicity and improve motor function; (3) Protein aggregation inhibitor prevent protein misfolding and accumulation; (4) MicroRNA modulator regulates apoptosis, Necroptosis, and inflammation; (5) Axonal transport modulator regulates posttranslational modifications of RNA binding proteins and other proteins; (6) Macrophage regulator prevents neuroinflammation and subsequent motor neurons degeneration; (7) C90rf72 inhibitor prevent modulation of downstream pathways; (8) Reactive oxygen species inhibitor prevent mitochondrial dysfunction and cell damage; (9) Apoptotic inhibitor prevent apoptosis and cell damage; (10) SOD1 inhibitor prevents protein aggregation; (11) Creatine kinase 1 inhibitor prevents phosphorylation of TDP-43 binding protein; (12) Neuromuscular junction modulator prevent loss of neuromuscular junction integrity