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Figure 4: This has been proposed by our group as a possible explanation for RVT effects against liver fibrosis. RVT is a lipophilic compound; it can readily cross the cell membrane and bind to intracellular components. It can also exert its action through binding to specific receptors. RVT act as a free radical scavenger; thus, it prevents the detrimental effect of ROS on hepatocytes. It may also bind to PKC domains and AFP enhancer region and returns them back to their normal activities. TAA = Thioacetamide, RVT = Resveratrol, ROS = Reactive oxygen species, GSH = reduced glutathione, ALT = Alanine aminotransferase, AST = aspartate aminotransferase, PKC = protein kinase C, AP-1 = Activator protein 1, MMP = Matrix metalloproteinase, AFP = Alpha 1-fetoprotein, ECM = Extracellular matrix component, NF-κB = Nuclear factor kappa B

Figure 4: This has been proposed by our group as a possible explanation for RVT effects against liver fibrosis. RVT is a lipophilic compound; it can readily cross the cell membrane and bind to intracellular components. It can also exert its action through binding to specific receptors. RVT act as a free radical scavenger; thus, it prevents the detrimental effect of ROS on hepatocytes. It may also bind to PKC domains and AFP enhancer region and returns them back to their normal activities. TAA = Thioacetamide, RVT = Resveratrol, ROS = Reactive oxygen species, GSH = reduced glutathione, ALT = Alanine aminotransferase, AST = aspartate aminotransferase, PKC = protein kinase C, AP-1 = Activator protein 1, MMP = Matrix metalloproteinase, AFP = Alpha 1-fetoprotein, ECM = Extracellular matrix component, NF-κB = Nuclear factor kappa B