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Figure 7: Chronic stress resulted in impaired spatial working memory in T-maze task and chronic Celastrus paniculatus treatment to stressed rats ameliorated working memory de.cits in these animals. (a) Number of days to reach 80% correct choice; (b) number of errors per 10 trials in the retention test of T-maze rewarded alteration task. Data are represented as mean ± standard error of the mean. NC: Normal control (n = 10). ST: Rats subjected to restraint stress for 21 days (6 h/day) (n = 10). ST + VE (n = 10), ST + CP-400 (n = 10), and ST + CP-600 (n = 10): Stressed rats subjected to 14 days of treatment with vehicle, Celastrus paniculatus 400 or 600 mg/kg, intraperitoneally, respectively. One-way ANOVA followed by Tukey's post hoc test. ***P = 0.01 normal versus stress, ###P < 0.001 stress versus stress + drug treatment

Figure 7: Chronic stress resulted in impaired spatial working memory in T-maze task and chronic <i>Celastrus paniculatus</i> treatment to stressed rats ameliorated working memory de.cits in these animals. (a) Number of days to reach 80% correct choice; (b) number of errors per 10 trials in the retention test of T-maze rewarded alteration task. Data are represented as mean ± standard error of the mean. NC: Normal control (<i>n</i> = 10). ST: Rats subjected to restraint stress for 21 days (6 h/day) (<i>n</i> = 10). ST + VE (<i>n</i> = 10), ST + CP-400 (<i>n</i> = 10), and ST + CP-600 (<i>n</i> = 10): Stressed rats subjected to 14 days of treatment with vehicle, <i>Celastrus paniculatus</i> 400 or 600 mg/kg, intraperitoneally, respectively. One-way ANOVA followed by Tukey's <i>post hoc</i> test. ***<i>P</i> = 0.01 normal versus stress, ###<i>P</i> < 0.001 stress versus stress + drug treatment