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Figure 2: Chronic stress increased anxiety-like behavior in elevated plus maze and chronic Celastrus paniculatus treatment to stressed rats decreased anxiety behavior in these animals. (a) Percentage time spent in open arms; (b) percentage number of open arms entries; (c) percentage time spent in closed arms; (d) percentage number of closed arms entries. Data are represented as mean ± standard error of the mean. NC: Normal control (n = 12). ST: Rats subjected to restraint stress for 21 days (6 h/day) (n = 12). ST + VE (n = 12), ST + CP-400 (n = 12), and ST + CP-600 (n = 12): Stressed rats subjected to 14 days of treatment with vehicle, Celastrus paniculatus 400 or 600 mg/kg, intraperitoneally, respectively. One-way ANOVA followed by Tukey's post hoc test. ***P < 0.001 normal versus stress. ##P < 0.01, ###P < 0.001 stress versus stress + drug treatment

Figure 2: Chronic stress increased anxiety-like behavior in elevated plus maze and chronic <i>Celastrus paniculatus</i> treatment to stressed rats decreased anxiety behavior in these animals. (a) Percentage time spent in open arms; (b) percentage number of open arms entries; (c) percentage time spent in closed arms; (d) percentage number of closed arms entries. Data are represented as mean ± standard error of the mean. NC: Normal control (<i>n</i> = 12). ST: Rats subjected to restraint stress for 21 days (6 h/day) (<i>n</i> = 12). ST + VE (<i>n</i> = 12), ST + CP-400 (<i>n</i> = 12), and ST + CP-600 (<i>n</i> = 12): Stressed rats subjected to 14 days of treatment with vehicle, Celastrus paniculatus 400 or 600 mg/kg, intraperitoneally, respectively. One-way ANOVA followed by Tukey's <i>post hoc</i> test. ***<i>P</i> < 0.001 normal versus stress. ##<i>P</i> < 0.01, ###<i>P</i> < 0.001 stress versus stress + drug treatment