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Figure 3: Fluorescence assay. Percentage inhibitory effect of Trigonella foenum graecum extract, trigonelline and positive controls on drug metabolizing enzymes cytochrome P3A4 and cytochrome P2D6 (values are mean ± standard error of the mean; n = 3). Ketoconazole dimethyl sulphoxide = ketoconazole dissolved in dimethyl sulphoxide, ketoconazole ethanol = ketoconazole dissolved in ethanol, TFG DMSO = Trigonella foenum graecum dissolved in dimethyl sulphoxide, TFG ethanol = Trigonella foenum graecum dissolved in ethanol, trigonelline DMSO = trigonelline dissolved in dimethyl sulphoxide, trigonelline ethanol = trigonelline dissolved in ethanol, quinidine DMSO = quinidine dissolved in dimethyl sulphoxide, quinidine ethanol = quinidine dissolved in ethanol

Figure 3: Fluorescence assay. Percentage inhibitory effect of Trigonella foenum graecum extract, trigonelline and positive controls on drug metabolizing enzymes cytochrome P3A4 and cytochrome P2D6 (values are mean ± standard error of the mean; n = 3). Ketoconazole dimethyl sulphoxide = ketoconazole dissolved in dimethyl sulphoxide, ketoconazole ethanol = ketoconazole dissolved in ethanol, TFG DMSO = Trigonella foenum graecum dissolved in dimethyl sulphoxide, TFG ethanol = Trigonella foenum graecum dissolved in ethanol, trigonelline DMSO = trigonelline dissolved in dimethyl sulphoxide, trigonelline ethanol = trigonelline dissolved in ethanol, quinidine DMSO = quinidine dissolved in dimethyl sulphoxide, quinidine ethanol = quinidine dissolved in ethanol