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Figure 1: Diagrammatic representation of the selected model with one compartment. Dose 1: First dose of bupivacaine injected in the lumbar plexus, Dose 2: Second dose of bupivacaine injected in the sciatic nerve site, Ka1: Absorption rate constant (first order) from the first depot compartment. Ka2: Absorption rate constant (first order) from the second depot compartment, Ke: Elimination rate constant from the central compartment. VC: Central volume of distribution

Figure 1: Diagrammatic representation of the selected model with one compartment. Dose 1: First dose of bupivacaine injected in the lumbar plexus, Dose 2: Second dose of bupivacaine injected in the sciatic nerve site, Ka1: Absorption rate constant (first order) from the first depot compartment. Ka2: Absorption rate constant (first order) from the second depot compartment, Ke: Elimination rate constant from the central compartment. VC: Central volume of distribution